Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA_1c.

ABSTRACT:

Introduction

Glycated hemoglobin can interfere with oxygen delivery and CO₂ removal during exercise. Additionally, pancreatic insufficiency increases oxidative stress and exacerbates exercise intolerance in people with cystic fibrosis (PwCF). This investigation sought to test the hypotheses that elevated Hemoglobin A_1c (HbA_1c) can negatively affect exercise parameters in PwCF and that reductions in oxidative stress can improve tissue oxygenation in individuals with elevated HbA_1c.

Methods

Twenty four PwCF were divided into two groups; normal HbA1c <5.7% (N-HbA_1c) and elevated HbA_1c >5.7% (E-HbA_1c). A maximal exercise test was conducted to obtain peak oxygen uptake (VO₂peak), VO₂

SUBMITTER: Quertermous BP 

PROVIDER: S-EPMC10184196 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature