The characteristics and clinical relevance of tumor fusion burden in non-EBV (+) gastric cancer with MSS.

ABSTRACT:

Background

Next-generation sequencing (NGS) is maturely applied for gene fusion detection. Although tumor fusion burden (TFB) has been identified as an immune marker for cancer, the relationship between these fusions and the immunogenicity and molecular characteristics of gastric cancer (GC) patients remains unclear. GCs have different clinical significance depending on their subtypes, and thus, this study aimed to investigate the characteristics and clinical relevance of TFB in non-Epstein-Barr-virus-positive (EBV+) GC with microsatellite stability (MSS).

Methods

A total of 319 GC patients from The Cancer Genome Atlas stomach adenocarcinoma (TCGA-STAD) and a cohort of 45-case from ENA (PRJEB25780) were included. The cohort characteristics and distribution of TFB among the p

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10184333 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature