Bacillus cereus extracellular vesicles act as shuttles for biologically active multicomponent enterotoxins.

ABSTRACT:

Background

Extracellular vesicles (EVs) from Gram-positive bacteria have gained considerable importance as a novel transport system of virulence factors in host-pathogen interactions. Bacillus cereus is a Gram-positive human pathogen, causing gastrointestinal toxemia as well as local and systemic infections. The pathogenicity of enteropathogenic B. cereus has been linked to a collection of virulence factors and exotoxins. Nevertheless, the exact mechanism of virulence factor secretion and delivery to target cells is poorly understood.

Results

Here, we investigate the production and characterization of enterotoxin-associated EVs from the enteropathogenic B. cereus strain NVH0075-95 by using a proteomics approach and studied their interaction with human host cells in vitro. Fo

SUBMITTER: Buchacher T 

PROVIDER: S-EPMC10184354 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature