Serum vitamin D levels and Sjogren's syndrome: bi-directional Mendelian randomization analysis.

ABSTRACT:

Background

Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren's syndrome (SS) in humans is still controversial. Based on this situation, this study aimed to assess the causal relationship between serum vitamin D levels and SS by using the Mendelian randomization (MR) approach.

Methods

In this study, genome-wide association studies (GWAS) summary statistics on serum vitamin D levels [sample size = 417,580 (UK Biobank)] and SS [sample size = 416,757 (cases = 2495, controls = 414,262) (FinnGen)] were used. The bi-directional MR analysis was then used to assess possible causal relationships. The major analysis method of MR was performed using inverse-variance weighted (IVW), suppleme

SUBMITTER: Zhao M 

PROVIDER: S-EPMC10184420 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature