Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer.

ABSTRACT:

Background

Lung cancer is a malignant tumour with the fastest increase in morbidity and mortality around the world. The clinical treatments available have significant side effects, thus it is desirable to identify alternative modalities to treat lung cancer. Shashen Maidong decoction (SMD) is a commonly used traditional Chinese medicine (TCM) formula for treating lung cancer in the clinic. While the key functional components (KFC) and the underlying mechanisms of SMD treating lung cancer are still unclear.

Methods

We propose a new integrated pharmacology model, which combines a novel node-importance calculation method and the contribution decision rate (CDR) model, to identify the KFC of SMD and to deduce their mechanisms in the treatment of lung cancer.

Results

The e

SUBMITTER: Cai J 

PROVIDER: S-EPMC10184424 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature