Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration.

ABSTRACT:

Background

Deer antlers are the only known mammalian structure that undergoes full regeneration. In addition, it is peculiar because when growing, it contains vascularized cartilage. The differentiation of antler stem cells (ASCs) into chondrocytes while inducing endochondral extension of blood vessels is necessary to form antler vascularized cartilage. Therefore, antlers provide an unparalleled opportunity to investigate chondrogenesis, angiogenesis, and regenerative medicine. A study found that Galectin-1 (GAL-1), which can be used as a marker in some tumors, is highly expressed in ASCs. This intrigued us to investigate what role GAL-1 could play in antler regeneration.

Methods

We measured the expression level of GAL-1 in antler tissues and cells by immunohistochemistry, W

SUBMITTER: Li X 

PROVIDER: S-EPMC10184426 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature