The brain-penetrant cell-cycle inhibitor p28 sensitizes brain metastases to DNA-damaging agents.

ABSTRACT:

Background

Brain metastases (BMs), the most common tumors of the central nervous system, are life-threatening with a dismal prognosis. The major challenges to developing effective treatments for BMs are the limited abilities of drugs to target tumors and to cross the blood-brain barrier (BBB). We aimed to investigate the efficacy of our therapeutic approach against BMs in mouse models that recapitulate the clinical manifestations of BMs.

Methods

BMs mouse models were constructed by injecting human breast, lung cancer, and melanoma intracardially, which allowed the BBB to remain intact. We investigated the ability of the cell-penetrating peptide p28 to cross the BBB in an in vitro 3D model and in the BMs animal models. The therapeutic effects of p28 in combination with DNA-da

SUBMITTER: Mander S 

PROVIDER: S-EPMC10184511 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature