Behavioral comparison of the C57BL/6 inbred mouse strain and their CB6F1 siblings.

ABSTRACT: A large portion of basic biomedical research studies are conducted using genetically defined, inbred mouse strains. The C57BL/6 mouse strain is the most widely used genetic background in current rodent research. The rationale for using inbred strains is that all individuals are genetically identical with minimal phenotypic variation, allowing for more statistically powerful analyses. F₁ hybrids between two inbred strains are also genetically identical to one another but are heterozygous at every locus at which the parental strains differ rather than homozygous. Both theoretical and empirical evidence suggests that this heterozygosity in F₁ hybrids allow for potentially greater resilience in response to the inevitable stresses of laboratory environments. The purpose of

SUBMITTER: Corder KM 

PROVIDER: S-EPMC10184519 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature