Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials.

ABSTRACT:

Rationale

Psychedelic research continues to garner significant public and scientific interest with a growing number of clinical studies examining a wide range of conditions and disorders. However, expectancy effects and effective condition masking have been raised as critical limitations to the interpretability of the research.

Objective

In this article, we review the many methodological challenges of conducting psychedelic clinical trials and provide recommendations for improving the rigor of future research.

Results

Although some challenges are shared with psychotherapy and pharmacology trials more broadly, psychedelic clinical trials have to contend with several unique sources of potential bias. The subjective effects of a high-dose psychedelic are often so pronoun

SUBMITTER: Aday JS 

PROVIDER: S-EPMC10184717 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature