Ontology highlight
ABSTRACT:
SUBMITTER: Moon KL
PROVIDER: S-EPMC10184777 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Moon Katherine L KL Huson Heather J HJ Morrill Kathleen K Wang Ming-Shan MS Li Xue X Srikanth Krishnamoorthy K Lindblad-Toh Kerstin K Svenson Gavin J GJ Karlsson Elinor K EK Shapiro Beth B
Science (New York, N.Y.) 20230428 6643
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat features atypical for modern sled dog breeds, and a slightly smaller stature. He had enhanc ...[more]