Integrative proteomic profiling of lung tissues and blood in acute respiratory distress syndrome.

ABSTRACT:

Introduction

Acute respiratory distress syndrome and acute lung injury (ARDS/ALI) still lack a recognized diagnostic test and pharmacologic treatments that target the underlying pathology.

Methods

To explore the sensitive non-invasive biomarkers associated with pathological changes in the lung of direct ARDS/ALI, we performed an integrative proteomic analysis of lung and blood samples from lipopolysaccharide (LPS)-induced ARDS mice and COVID-19-related ARDS patients. The common differentially expressed proteins (DEPs) were identified based on combined proteomic analysis of serum and lung samples in direct ARDS mice model. The clinical value of the common DEPs was validated in lung and plasma proteomics in cases of COVID-19-related ARDS.

Results

We identified 368 DEPs

SUBMITTER: Gong R 

PROVIDER: S-EPMC10184823 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature