Home-site advantage for host species-specific gut microbiota.

ABSTRACT: Mammalian species harbor compositionally distinct gut microbial communities, but the mechanisms that maintain specificity of symbionts to host species remain unclear. Here, we show that natural selection within house mice (Mus musculus domesticus) drives deterministic assembly of the house-mouse gut microbiota from mixtures of native and non-native microbiotas. Competing microbiotas from wild-derived lines of house mice and other mouse species (Mus and Peromyscus spp.) within germ-free wild-type (WT) and Rag1-knockout (Rag1^-/-) house mice revealed widespread fitness advantages for native gut bacteria. Native bacterial lineages significantly outcompeted non-native lineages in both WT and Rag1^-/- mice, indicating home-site advan

SUBMITTER: Sprockett DD 

PROVIDER: S-EPMC10184861 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature