Multiple thiol-anchor capped DNA-gold nanoparticle conjugates.

ABSTRACT: We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.

SUBMITTER: Li Z 

PROVIDER: S-EPMC101851 | biostudies-literature | 2002 Apr

REPOSITORIES: biostudies-literature