Two-state model explaining thermodynamic regulation of thermo-gating channels.

ABSTRACT: Temperature-sensitive ion channels, such as those from the TRP family (thermo-TRPs) present in all animal cells, serve to perceive heat and cold sensations. A considerable number of protein structures have been reported for these ion channels, providing a solid basis for revealing their structure-function relationship. Previous functional studies suggest that the thermosensing ability of TRP channels is primarily determined by the properties of their cytosolic domain. Despite their importance in sensing and wide interests in the development of suitable therapeutics, the precise mechanisms underlying acute and steep temperature-mediated channel gating remain enigmatic. Here, we propose a model in which the thermo-TRP channels directly sense external temperature through the formation and dis

SUBMITTER: Zhang XC 

PROVIDER: S-EPMC10185483 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature