Recurrent nephrolithiasis and loss of kidney function: a cohort study.

ABSTRACT:

Purpose

To evaluate whether symptomatic recurrent nephrolithiasis leads to loss of kidney function.

Methods

Adults who presented to the Emergency Department at least twice with symptomatic and radiologically confirmed nephrolithiasis were retrospectively recruited. Primary endpoint was the change in glomerular filtration rate (GFR) between baseline and at the time of data collection. Secondary endpoints include GFR slope defined as the mean rate of change in GFR from baseline to the end of the study period.

Results

240 patients had recurrent symptomatic nephrolithiasis. Median follow-up was 5.4 years. The median age of first acute presentation was 51.6 years and the median baseline serum creatinine (bsCr) was 85.5 umol/l. 17.5% (n = 42) had worsening GFR, with the ave

SUBMITTER: Tan RYP 

PROVIDER: S-EPMC10185628 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature