Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.

ABSTRACT:

Objective

To examine the association between isolated maternal hypothyroxinaemia (IMH) and adverse obstetric outcomes and offspring outcomes and also investigate the effects of levothyroxine therapy on IMH for the above outcomes.

Methods

We systematically searched PubMed, EMBASE, and Cochrane Library, and the reference lists of key reviews were hand searched on June 9, 2021. Two authors independently screened titles/abstracts. Full articles were further assessed if the information suggested that the study met the inclusion/exclusion criteria, and two researchers performed data extraction and risk-of-bias assessment using standardized tables. Summary relative risks or the mean difference between maternal effects and offspring outcomes were calculated by a random-effects model

SUBMITTER: Zhuo L 

PROVIDER: S-EPMC10185648 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature