Edge and modular significance assessment in individual-specific networks.

ABSTRACT: Individual-specific networks, defined as networks of nodes and connecting edges that are specific to an individual, are promising tools for precision medicine. When such networks are biological, interpretation of functional modules at an individual level becomes possible. An under-investigated problem is relevance or "significance" assessment of each individual-specific network. This paper proposes novel edge and module significance assessment procedures for weighted and unweighted individual-specific networks. Specifically, we propose a modular Cook's distance using a method that involves iterative modeling of one edge versus all the others within a module. Two procedures assessing changes between using all individuals and using all individuals but leaving one individual out (LOO) are pro

SUBMITTER: Melograna F 

PROVIDER: S-EPMC10185658 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature