Association of CYP2R1 and CYP27B1 genes with the risk of obesity and vitamin D metabolism in Saudi women.

ABSTRACT:

Background

Epigenome, genetic variants, and other environmental factors involved in gene regulation are highly inter-dependent in several chronic diseases, including obesity, cardiovascular disease, and diabetes. The present study aimed at testing the associations and the mechanism involved in silencing of CYP2R1 gene in normal and obese Saudi women patients. Height, weight, BMI, 25-hydroxy vitamin D, parathyroid hormone, glycemic status, and lipid profile (TG, LDL, HDL, and TC) of CYP2R1 were measured in 100 women (31 normal and 69 obese patients).

Results

Our result shows that hypermethylation in site 2 of the CYP2R1 gene with body weight (p < 0.004), BMI (p < 0.002), waist circumference (p < 0.002), total-LDL (p < 0.027), total cholesterol (p < 0.022), and vitamin D (VD)

SUBMITTER: AlSedairy SA 

PROVIDER: S-EPMC10185724 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature