Disentangling the effects of obesity and high-fat diet on glucose homeostasis using a photoperiod induced obesity model implicates ectopic fat deposition as a key factor.

ABSTRACT:

Objective

Obesity in laboratory rodents is generally induced by feeding them a high fat diet (HFD). This model does not permit separation of the impact of the HFD from the resultant obesity on metabolic defects such as impaired glucose homeostasis. In Brandt's voles we have previously shown that exposure to long photoperiod (LD: 16L: 8D) induces obesity even when they are fed a low fat diet. We show here that these voles are largely resistant to HFD. This model therefore permits some separation of the effects of HFD and obesity on glucose homeostasis. The objective was therefore to use this model to assess if glucose homeostasis is more related to diet or obesity METHODS: Male voles, which were 35 days old and born in LD, were exposed to SD and a low fat diet for 70 days. We then r

SUBMITTER: Yang DB 

PROVIDER: S-EPMC10185741 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature