Injectable thermo-sensitive hydrogel loaded hollow copper sulfide nanoparticles for ROS burst in TME and effective tumor treatment.

ABSTRACT: Introduction: Lung cancer the most prevalent cause of cancer-related deaths, and current therapies lack sufficient specificity and efficacy. This study developed an injectable thermosensitive hydrogel harboring hollow copper sulfide nanoparticles and β-lapachone (Lap) (CLH) for lung tumor treatment. Methods: The hydrogel-encapsulated CLH system can remotely control the release of copper ions (Cu²⁺) and drugs using photothermal effects for non-invasive controlled-release drug delivery in tumor therapy. The released Cu²⁺ consumes the overexpressed GSH in TME and the generated Cu⁺ further exploits the TME characteristics to initiate nanocatalytic reactions for generating highly toxic hydroxyl radicals. In addition, in cancer cells overexpressing

SUBMITTER: Ning S 

PROVIDER: S-EPMC10185793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature