Gut microbiota dysbiosis with hepatitis B virus liver disease and association with immune response.

ABSTRACT:

Background and aims

Given hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC) exhibits unique gut microbiota characteristics and a significant immunosuppressive tumor microenvironment. Thus, a better understanding of the correlation between gut microbiota and the immunosuppressive response may help predict occurrence and prognosis of HBV-HCC.

Methods

Here, in a cohort of ninety adults (healthy control n=30, HBV-cirrhosis n=30, HBV-HCC n=30) with clinical data, fecal 16S rRNA gene sequencing, matched peripheral blood immune response with flow cytometry analysis. Correlation between the gut microbiome of significantly different in HBV-HCC patients and clinical parameters as well as the peripheral immune response was assessed.

Results

We found that communi

SUBMITTER: Yan F 

PROVIDER: S-EPMC10185817 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature