Basophils beyond allergic and parasitic diseases.

ABSTRACT: Basophils bind IgE via FcεRI-αβγ_2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease. This fundamental similarity, along with some morphological features shared by the two cell types, has long brought into question the biological significance that basophils mediate beyond that of mast cells. Unlike mast cells, which mature and reside in tissues, basophils are released into circulation from the bone marrow (constituting 1% of leukocytes), only to infiltrate tissues under specific inflammatory conditions. Evidence is emerging that basophils mediate non-redundant roles in allergic disease and, unsuspectingly, are implicated in a variety of other pathologies [e.g., myocardial infarction, autoi

SUBMITTER: Poto R 

PROVIDER: S-EPMC10185837 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature