Oncogenic role and drug sensitivity of ETV4 in human tumors: a pan-cancer analysis.

ABSTRACT:

Background

Increasing evidence supports a relationship between E twenty-six variant transcription factor 4 (ETV4) and several cancers, but no pan-cancer analysis has been reported.

Methods

The present study surveyed the effects of ETV4 on cancer using RNA sequencing data obtained from The Cancer Genome Atlas and GTEx, and further explored its role in drug sensitivity using data from Cellminer. Differential expression analyses were conducted for multiple cancers using R software. Cox regression and survival analysis were employed to calculate correlations between ETV4 levels and survival outcomes in multiple cancers using the online tool Sangerbox. ETV4 expression was also compared with immunity, heterogeneity, stemness, mismatch repair genes, and DNA methylation among differ

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10185867 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature