A systematic review on sex differences in adverse drug reactions related to psychotropic, cardiovascular, and analgesic medications.

ABSTRACT: Background and objective: Adverse drug reactions (ADRs) are the main safety concerns of clinically used medications. Accumulating evidence has shown that ADRs can affect men and women differently, which suggests sex as a biological predictor in the risk of ADRs. This review aims to summarize the current state of knowledge on sex differences in ADRs with the focus on the commonly used psychotropic, cardiovascular, and analgesic medications, and to aid clinical decision making and future mechanistic investigations on this topic. Methods: PubMed search was performed with combinations of the following terms: over 1,800 drugs of interests, sex difference (and its related terms), and side effects (and its related terms), which yielded over 400 unique articles. Articles related to p

SUBMITTER: Shan Y 

PROVIDER: S-EPMC10185891 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature