The application of autologous cancer immunotherapies in the age of memory-NK cells.

ABSTRACT: Cellular immunotherapy has revolutionized the oncology field, yielding improved results against hematological and solid malignancies. NK cells have become an attractive alternative due to their capacity to activate upon recognition of "stress" or "danger" signals independently of Major Histocompatibility Complex (MHC) engagement, thus making tumor cells a perfect target for NK cell-mediated cancer immunotherapy even as an allogeneic solution. While this allogeneic use is currently favored, the existence of a characterized memory function for NK cells ("memory-like" NK cells) advocates for an autologous approach, that would benefit from the allogeneic setting discoveries, but with added persistence and specificity. Still, both approaches struggle to exert a sustained and high anticancer eff

SUBMITTER: Lizana-Vasquez GD 

PROVIDER: S-EPMC10185894 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature