Operationalizing the centiloid scale for [¹⁸F]florbetapir PET studies on PET/MRI.

ABSTRACT:

Introduction

The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI).

Methods

We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian-mixture-modelling-derived cutpoints for Aβ PET positivity were converted.

Results

The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake

SUBMITTER: Coath W 

PROVIDER: S-EPMC10186069 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature