Management of Lung Cancer Screening Results Based on Individual Prediction of Current and Future Lung Cancer Risks.

ABSTRACT:

Objectives

We propose a risk-tailored approach for management of lung cancer screening results. This approach incorporates individual risk factors and low-dose computed tomography (LDCT) image features into calculations of immediate and next-screen (1-y) risks of lung cancer detection, which in turn can recommend short-interval imaging or 1-year or 2-year screening intervals.

Methods

We first extended the "LCRAT+CT" individualized risk calculator to predict lung cancer risk after either a negative or abnormal LDCT screen result. To develop the abnormal screen portion, we analyzed 18,129 abnormal LDCT results in the National Lung Screening Trial (NLST), including lung cancers detected immediately (n = 649) or at the next screen (n = 235). We estimated the potential impact of

SUBMITTER: Robbins HA 

PROVIDER: S-EPMC10186153 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature