PD-1 limits differentiation and plasticity of Tc17 cells.

ABSTRACT: Blockade of surface co-inhibitory receptor programmed cell death-1 (PD-1; CD279) has been established as an important immunotherapeutic approach to treat malignancies. On a cellular level, PD-1 is demonstrated to be of particular importance in inhibiting differentiation and effector function of cytotoxic Tc1 cells (CTLs). Nevertheless, the role of PD-1 in modulating interleukin (IL)-17-producing CD8⁺ T-cells (Tc17 cells), which generally display suppressed cytotoxic nature, is not well understood. To evaluate the impact of PD-1 in Tc17 responses, we examined its functioning using different in vitro and in vivo models. Upon activation of CD8⁺ T-cells in Tc17 environment, we found that PD-1 was rapidly expressed on the surface of CD8⁺ T-cells an

SUBMITTER: Arra A 

PROVIDER: S-EPMC10186197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature