Association of Bone Mineral Density and Dementia: The Rotterdam Study.

ABSTRACT:

Background and objectives

Low bone mineral density (BMD) and dementia commonly co-occur in older individuals, with bone loss accelerating in patients with dementia due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists before onset of dementia. Therefore, we investigated how dementia risk was affected by BMD at various skeletal regions in community-dwelling older adults.

Methods

In a prospective population-based cohort study, BMD at the femoral neck, lumbar spine, and total body and the trabecular bone score (TBS) were obtained using dual-energy X-ray absorptiometry in 3,651 participants free from dementia between 2002 and 2005. Persons at risk of dementia were followed up until January 1, 2020. For anal

SUBMITTER: Xiao T 

PROVIDER: S-EPMC10186235 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature