Integrating CT-based radiomic model with clinical features improves long-term prognostication in high-risk prostate cancer.

ABSTRACT:

Objective

High-risk prostate cancer (PCa) is often treated by prostate-only radiotherapy (PORT) owing to its favourable toxicity profile compared to whole-pelvic radiotherapy. Unfortunately, more than 50% patients still developed disease progression following PORT. Conventional clinical factors may be unable to identify at-risk subgroups in the era of precision medicine. In this study, we aimed to investigate the prognostic value of pre-treatment planning computed tomography (pCT)-based radiomic features and clinical attributes to predict 5-year progression-free survival (PFS) in high-risk PCa patients following PORT.

Materials and methods

A total of 176 biopsy-confirmed PCa patients who were treated at the Hong Kong Princess Margaret Hospital were retrospectively screened f

SUBMITTER: Ching JCF 

PROVIDER: S-EPMC10186349 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature