Predicting Vibrio cholerae infection and symptomatic disease: a systems serology study.

ABSTRACT:

Background

Vibriocidal antibodies are currently the best characterised correlate of protection against cholera and are used to gauge immunogenicity in vaccine trials. Although other circulating antibody responses have been associated with a decreased risk of infection, the correlates of protection against cholera have not been comprehensively compared. We aimed to analyse antibody-mediated correlates of protection from both V cholerae infection and cholera-related diarrhoea.

Methods

We conducted a systems serology study that analysed 58 serum antibody biomarkers as correlates of protection against V cholerae O1 infection or diarrhoea. We used serum samples from two cohorts: household contacts of people with confirmed cholera in Dhaka, Bangladesh, and cholera-naive volunteers

SUBMITTER: Wiens KE 

PROVIDER: S-EPMC10186354 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature