Rising NAFLD and metabolic severity during the Sars-CoV-2 pandemic among children with obesity in the United States.

ABSTRACT:

Objective

Nonalcoholic fatty liver disease (NAFLD), the most common liver disease among youth with obesity, precedes more severe metabolic and liver diseases. However, the impact of the Sars-CoV-2 global pandemic on the prevalence and severity of NAFLD and the associated metabolic phenotype among youth with obesity is unknown.

Methods

Participants were recruited from the Yale Pediatric Obesity Clinic during the Sars-CoV-2 global pandemic (August 2020 to May 2022) and were compared with a frequency-matched control group of youth with obesity studied before the Sars-CoV-2 global pandemic (January 2017 to November 2019). Glucose metabolism differences were assessed during an extended 180-minute oral glucose tolerance test. Magnetic resonance imaging-derived proton density fat f

SUBMITTER: Slusher AL 

PROVIDER: S-EPMC10186584 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature