Paternal genetic effects of cadmium exposure during pregnancy on hormone synthesis disorders in ovarian granulosa cells of offspring.

ABSTRACT: The aim of this study was to investigate the paternal genetic intergenerational and transgenerational genetic effects of cadmium (Cd) exposure during pregnancy on estradiol (E₂) and progesterone (Pg) synthesis in the ovarian granulosa cells (GCs) of offspring. Pregnant SD rats were intragastrically exposed to CdCl₂ (0, 0.5, 2.0, 8.0 mg/kg) from days 1 to 20 to produce the F1 generation, F1 males were mated with newly purchased females to produce the F2 generation, and the F3 generation was obtained in the same way. Using this model, Cd-induced hormone synthesis disorders in GCs of F1 have been observed [8]. In this study, altered serum E₂ and Pg levels in both F2 and F3 generations showed a nonmonotonic dose‒response relationship. In addition, hormone synth

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10186638 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature