Poly(2-oxazoline)-based core cross-linked star polymers: synthesis and drug delivery applications.

ABSTRACT: Poly(2-oxazoline)s (POxs) are promising platforms for drug delivery applications due to their biocompatibility and stealth properties. In addition, the use of core cross-linked star (CCS) polymers based on POxs is expected to enhance drug encapsulation and release performances. In this study, we employed the "arm-first" strategy to synthesize a series of amphiphilic CCS [poly(2-methyl-2-oxazoline)]_n-block-poly(2,2'-(1,4-phenylene)bis-2-oxazoline)-cross-link/copolymer-(2-n-butyl-2-oxazoline)s (PMeOx)_n-b-P(PhBisOx-cl/co-ButOx)s by using microwave-assisted cationic ring-opening polymerization (CROP). First, PMeOx, as the hydrophilic arm, was synthesized by CROP of MeOx using methyl tosylate as the initiator. Subsequently,

SUBMITTER: Alkattan N 

PROVIDER: S-EPMC10187039 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature