The unreversible reduced but persistent activated NK and CD8⁺ T cells in severe/critical COVID-19 during omicron pandemic in China.

ABSTRACT: As a hallmark of COVID-19 progression, lymphopenia alongside its subtle immune disturbance has been widely reported, but yet to be thoroughly elucidated. Aiming at exploring clinical immune biomarkers with accessibility in the current and acute omicron epidemic abrupted in China post-control era, we design a real-world prospective observation cohort in Peking Union Medical College Hospital to describe immunological, haematological profiles inducing lymphocyte subsets related to SARS-CoV-2 infection. In this COVID-19 cohort, we enrolled 17 mild/moderate (M/M), 24 severe (S) and 25 critical (C) patients. The dynamics of lymphocytes of COVID-19 demonstrated that the sharp decline of NK, CD8⁺, and CD4⁺ T cell counts was the main contributor to lymphopenia in the S/C group

SUBMITTER: Qin L 

PROVIDER: S-EPMC10187090 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature