Potential use of endemic human coronaviruses to stimulate immunity against pathogenic SARS-CoV-2 and its variants.

ABSTRACT: While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes significant morbidity and mortality in humans, there is a wide range of disease outcomes following virus exposures. Some individuals are asymptomatic while others develop complications within a few days after infection that can lead to fatalities in a smaller portion of the population. In the present study, we have analyzed the factors that may influence the outcome of post-SARS-CoV-2 infection. One factor that may influence virus control is pre-existing immunity conferred by an individual's past exposures to endemic coronaviruses (eCOVIDs) which cause the common cold in humans and generally, most children are exposed to one of the four eCOVIDs before 2 years of age. Here, we have carried out protein sequence analyse

SUBMITTER: Shamabadi NS 

PROVIDER: S-EPMC10187108 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature