Evolutionary Insights from a Large-scale Survey of Population-genomic Variation.

ABSTRACT: Results from data on > 1000 haplotypes distributed over a nine-year period from a natural population of the microcrustacean Daphnia pulex reveal evolutionary-genomic features at a refined scale, including key population-genetic properties that are obscured in studies with smaller sample sizes. Background selection, resulting from the recurrent introduction of deleterious alleles, appears to strongly influence the dynamics of neutral alleles, inducing indirect negative selection on rare variants and positive selection on common variants. Fluctuating selection increases the persistence of nonsynonymous alleles with intermediate frequencies, while reducing standing levels of variation at linked silent sites. Combined with the results from an equally large metapopulation survey of the s

SUBMITTER: Ye Z 

PROVIDER: S-EPMC10187179 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature