Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy.

ABSTRACT: Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature immune system but how vaccine-induced antibodies transfer to the placenta and protect the maternal-fetal dyad remains unclear. Here, we compare matched maternal-infant cord blood from individuals who in pregnancy received mRNA COVID-19 vaccine, were infected by SARS-CoV-2, or had the combination of these two immune exposures. We find that some but not all antibody neutralizing activities and Fc effector functions are enriched with vaccination compared to infection. Preferential transport to the fetus of Fc functions and not neutralization is observed. Immunization compared to infection enriches IgG1-mediated antibody functions with changes in antibody post-translational sialylation and

SUBMITTER: Adhikari EH 

PROVIDER: S-EPMC10187183 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature