A leaky integrate-and-fire computational model based on the connectome of the entire adult <i>Drosophila</i> brain reveals insights into sensorimotor processing.

ABSTRACT: The forthcoming assembly of the adult Drosophila melanogaster central brain connectome, containing over 125,000 neurons and 50 million synaptic connections, provides a template for examining sensory processing throughout the brain. Here, we create a leaky integrate-and-fire computational model of the entire Drosophila brain, based on neural connectivity and neurotransmitter identity, to study circuit properties of feeding and grooming behaviors. We show that activation of sugar-sensing or water-sensing gustatory neurons in the computational model accurately predicts neurons that respond to tastes and are required for feeding initiation. Computational activation of neurons in the feeding region of the Drosophila brain predicts those that elicit motor neuron firing, a te

SUBMITTER: Shiu PK 

PROVIDER: S-EPMC10187186 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature