Integrative multi-dimensional characterization of striatal projection neuron heterogeneity in adult brain.

ABSTRACT: Striatal projection neurons (SPNs) are traditionally segregated into two subpopulations expressing dopamine (DA) D₁-like or D₂-like receptors. However, this dichotomy is challenged by recent evidence. Functional and expression studies raise important questions: do SPNs co-express different DA receptors, and do these differences reflect unique striatal spatial distributions and expression profiles? Using RNAscope in mouse striatum, we report heterogenous SPN subpopulations distributed across dorsal-ventral and rostral-caudal axes. SPN subpopulations co-express multiple DA receptors, including D₁ and D₂ (D1/2R) and D₁ and D₃. Our integrative approach using single-nuclei multi-omics analyses provides a simple consensus to descr

SUBMITTER: Gayden J 

PROVIDER: S-EPMC10187292 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature