Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability.

ABSTRACT: The insula is a portion of the cerebral cortex folded deep within the lateral sulcus covered by the overlying opercula of the inferior frontal lobe and superior portion of the temporal lobe. The insula has been parsed into sub-regions based upon cytoarchitectonics and structural and functional connectivity with multiple lines of evidence supporting specific roles for each of these sub-regions in pain processing and interoception. In the past, causal interrogation of the insula was only possible in patients with surgically implanted electrodes. Here, we leverage the high spatial resolution combined with the deep penetration depth of low-intensity focused ultrasound (LIFU) to non-surgically modulate either the anterior insula (AI) or posterior insula (PI) in humans for effect on subjective p

SUBMITTER: Legon W 

PROVIDER: S-EPMC10187309 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature