Systematic review of genotype-stratified treatment for monogenic insulin resistance.

ABSTRACT:

Objective

To assess the effects of pharmacologic and/or surgical interventions in monogenic insulin resistance (IR), stratified by genetic aetiology.

Design

Systematic review.

Data sources

PubMed, MEDLINE and Embase, from 1 January 1987 to 23 June 2021.

Review methods

Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR were eligible. Individual subject data were extracted and duplicate data removed. Outcomes were analyzed for each affected gene and intervention, and in aggregate for partial, generalised and all lipodystrophy.

Results

10 non-randomised experimental studies, 8 case series, and 21 single case reports met inclusion criteria, all rated as having moderate or serious risk of bias. Metrelepti

SUBMITTER: Semple RK 

PROVIDER: S-EPMC10187355 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature