Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.

ABSTRACT: Although CGRP neurons in the external lateral parabrachial nucleus (PBel^CGRP neurons) are critical for cortical arousal in response to hypercapnia, activating them has little effect on respiration. However, deletion of all Vglut2 expressing neurons in the PBel region suppresses both the respiratory and arousal response to high CO2. We identified a second population of non-CGRP neurons adjacent to the PBel^CGRP group in the central lateral, lateral crescent and Kölliker-Fuse parabrachial subnuclei that are also activated by CO2 and project to the motor and premotor neurons that innvervate respiratory sites in the medulla and spinal cord. We hypothesize that these neurons may in part mediate the respiratory response to CO2 and that they may express the transcription fact

SUBMITTER: Kaur S 

PROVIDER: S-EPMC10187408 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature