Prolonged activation of EP3 receptor-expressing preoptic neurons underlies torpor responses.

ABSTRACT: Many species use a temporary drop in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity. A similar profound hypothermia is observed with activation of preoptic neurons that express the neuropeptides Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP)¹, Brain Derived Neurotrophic Factor (BDNF)², or Pyroglutamylated RFamide Peptide (QRFP)³, the vesicular glutamate transporter, Vglut2^4,5 or the leptin receptor⁶ (LepR), estrogen 1 receptor (Esr1)⁷ or prostaglandin E receptor 3 (EP3R) in mice⁸. However, most of these genetic markers are found on multiple populations of preoptic neurons and only partially overlap with one another. We report here that expression of the EP3R marks a

SUBMITTER: Machado NLS 

PROVIDER: S-EPMC10187418 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature