Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.

ABSTRACT:

Background

Tumour-promoting inflammation is a "hallmark" of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear.

Methods

We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,162 cancer cases and up to 824,556 controls. Genetic instruments for inflammatory markers were constructed using genome-wide

SUBMITTER: Yarmolinsky J 

PROVIDER: S-EPMC10187459 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature