Occupational trichloroethylene exposure and antinuclear antibodies: a cross-sectional study in China.

ABSTRACT:

Objectives

There has been concern over the possible risk of autoimmune diseases from exposure to trichloroethylene (TCE), an industrial solvent and common pollutant near hazardous waste sites. Studies of TCE-exposed lupus-prone mouse strains have reported increases in serum antinuclear antibodies (ANAs), a marker of autoimmunity, and autoimmune pathologic changes, while epidemiologic studies have provided limited support for an association between TCE exposure and scleroderma. To investigate exposure-related biologic evidence of autoimmunity in humans, we measured ANA levels in sera from a cross-sectional study of TCE-exposed (n=80) and TCE-unexposed (n=96) workers in Guangdong, China.

Methods

Full-shift personal air exposure measurements for TCE were taken prior to blood co

SUBMITTER: Purdue M 

PROVIDER: S-EPMC10187559 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature