Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity.

ABSTRACT: The biomechanical properties of extracellular matrices (ECM) and their consequences for cellular homeostasis have recently emerged as a driver of aging. Here we review the age-dependent deterioration of ECM in the context of our current understanding of the aging processes. We discuss the reciprocal interactions of longevity interventions with ECM remodeling. And the relevance of ECM dynamics captured by the matrisome and the matreotypes associated with health, disease, and longevity. Furthermore, we highlight that many established longevity compounds promote ECM homeostasis. A large body of evidence for the ECM to qualify as a hallmark of aging is emerging, and the data in invertebrates is promising. However, direct experimental proof that activating ECM homeostasis is sufficient to slow

SUBMITTER: Statzer C 

PROVIDER: S-EPMC10187690 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature