KRT5⁺/p63⁺ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging.

ABSTRACT: Adult lungs present high cellular plasticity against stress and injury, mobilizing stem/progenitor populations from conducting airways to maintain tissue homeostasis and gas exchange in alveolar spaces. With aging, pulmonary functional and structural deterioration occurs, mainly in pathological conditions, which is associated with impaired stem cell activity and increased senescence in mice. However, the impact of these processes underlying lung physiopathology in relation to aging has not been explored in humans. In this work, we analyzed stem cell (SOX2, p63, KRT5), senescence (p16^INK4A, p21^CIP, Lamin B1) and proliferative (Ki67) markers in lung samples from young and aged individuals, with and without pulmonary pathology. We identified a reduction in SOX2⁺

SUBMITTER: Moreno-Valladares M 

PROVIDER: S-EPMC10187699 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature