Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease.

ABSTRACT:

Objective

To compute penetrance and recurrence risk using a genome-wide PRS (including and excluding the APOE region) in families with Alzheimer's disease.

Methods

Genotypes from the National Institute on Aging Late-Onset Alzheimer's Disease Family-Based Study and a study of familial Alzheimer's disease in Caribbean Hispanics were used to compute PRS with and without variants in the 2 MB region flanking APOE. PRS was calculated in using clumping/thresholding and Bayesian methods and was assessed for association with Alzheimer's disease and age at onset. Penetrance and recurrence risk for carriers in highest and lowest PRS quintiles were compared separately within APOE-ε4 carriers and non-carriers.

Results

PRS excluding the APOE region was strongly associated with clin

SUBMITTER: Qiao M 

PROVIDER: S-EPMC10187719 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature