Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait.

ABSTRACT:

Background

Mounting research support that cholinergic dysfunction plays a prominent role in freezing of gait (FOG), which commonly occurs in Parkinson's disease (PD). Basal forebrain (BF), especially the cholinergic nuclei 4 (Ch4), provides the primary source of the brain cholinergic input. However, whether the degeneration of BF and its innervated cortex contribute to the pathogenesis of FOG is unknown.

Objective

To explore the role of structural alterations of BF and its innervated cortical brain regions in the pathogenesis of PD patients with freezing.

Methods

Magnetic resonance imaging assessments and neurological assessments were performed on 20 PD patients with FOG (PD-FOG), 20 without FOG (PD-NFOG), and 21 healthy participants. Subregion volumes of the BF were

SUBMITTER: Gan C 

PROVIDER: S-EPMC10187724 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature